12/11/21

BNT162b2 Messenger RNA COVID-19 Vaccine Effectiveness in Patients With Inflammatory Bowel Disease: Preliminary Real-World Data During Mass Vaccination Campaign

Amir Ben-Tov, Tamar Banon, Gabriel Chodick, Revital Kariv, Amit Assa, Sivan Gazit, Collaborators of the Maccabi Institute for Research & Innovation COVID-19 Task Force A 2-dose regimen of the BNT162b2 messenger (m)RNA COVID-19 vaccine (Pfizer-BioNTech; Pfizer, New York, NY) has…
12/11/21

ECCO Topical Review: Refractory Inflammatory Bowel Disease

Tim Raine, Bram Verstockt, Uri Kopylov, Konstantinos Karmiris, Rimma Goldberg, Raja Atreya, Johan Burisch, John Burke, Pierre Ellul, Charlotte Hedin, Stefan D Holubar, Konstantinos Katsanos, Triana Lobaton, Carsten Schmidt, Garret Cullen Abstract Inflammatory bowel disease is a chronic disease with…
12/11/21

Loss of response to anti-TNFa agents depends on treatment duration in patients with inflammatory bowel disease

Summary Background: Inflammatory bowel disease (IBD) is often managed with anti-tumour necrosis factor-therapy (anti--TNFa), but treatment efficacy is compromised by high annual rates of loss of response (13%-21% per patient-year). Aims: To assess whether the incidence of loss of response…
12/11/21

Occurrence of Colorectal Cancer and the Influence of Medical Treatment in Patients With Inflammatory Bowel Disease: A Danish Nationwide Cohort Study, 1997 to 2015

Petra Weimers, MD, Dorit Vedel Ankersen, MSc, Ellen Christine Leth Løkkegaard, PhD, Johan Burisch, PhD, Pia Munkholm, PhDInflammatory Bowel Diseases, Volume 27, Issue 11, November 2021, Pages 1795–1803, Background: The risk of colorectal cancer (CRC) for patients with inflammatory bowel…
12/11/21

The Risk of Later Diagnosis of Inflammatory Bowel Disease in Patients With Dermatological Disorders Associated With Inflammatory Bowel Disease

Dominic King, MBChB, Joht Singh Chandan, PhD, Tom Thomas, MBBD, Krishnarajah Nirantharakumar, MD, Raoul C Reulen, PhD, Nicola J Adderley, PhD, Nigel Trudgill, MDInflammatory Bowel Diseases, Volume 27, Issue 11, November 2021, Pages 1731–1739 Background: Dermatological conditions such as erythema…
10/09/21

Risk of Venous Thromboembolism Among Inflammatory Bowel Disease Patients Who Contract SARS-CoV-2

Nadim Mahmud, MD1,2; Alexandra Weiss, MD2; Chinmay Trivedi, MBBS1; Yu-Xiao Yang, MD1,3; James Lewis, MD2; Nabeel Khan, MD1,2Gastroenterology 2021 Jun 15;S0016-5085(21)03123-1. Introduction : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic affecting over 166 million people…
10/09/21

Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection

JR Allegretti, CR Kelly , A Grinspan, BH Mullish, J Hurtado, M Carrellas, J Marcus, JR Marchesi , JAK McDonald , Y Gerardin, M Silverstein, A Pechlivanis , GF Barker, JM Blanco, JL Alexander, KI Gallagher, W Pettee, E Phelps, …
10/09/21

Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease:long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

Evangelos Stournaras, Wendi Qian , Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators; Tim Raine, Miles Parkes.Gut 2021 Apr;70(4):677-686 Abstract Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base…
10/09/21

Immunogenicity of Tumor Necrosis Factor Antagonists and Effect of Dose Escalation on Anti-Drug Antibodies and Serum Drug Concentrations in Inflammatory Bowel Disease

Robert Battat, MD, Dana Lukin, MD, PhD, Ellen J Scherl, MD, Suresh Pola, MD, Anand Kumar, MD, Lauren Okada, Lei Yang, PhD, Anjali Jain, PhD, Corey A Siegel, MD, MSInflammatory Bowel Diseases, Volume 27, Issue 9, September 2021, Pages 1443–1451…
10/09/21

Comparison of short- and long-term effectiveness between ustekinumab and vedolizumab in patients with Crohn's disease refractory to anti-tumour necrosis factor therapy

Luc Manlay, Gilles Boschetti, Bruno Pereira, Bernard Flourié, Michel Dapoigny, Maud Reymond, Elisa Sollelis, Claire Gay, Mathilde Boube, Anthony Buisson, Stéphane NanceyAliment Pharmacol Ther 2021 Jun;53(12):1289-1299 Abstract BackgroundThe best option between vedolizumab and ustekinumab after anti-tumour necrosis factor (TNF) failure…
05/07/21

Tofacitinib for the Treatment of Ulcerative Colitis: Analysis of Infection Rates from the Ulcerative Colitis Clinical Programme

Kevin L Winthrop, Edward V Loftus, Jr, Daniel C Baumgart, Walter Reinisch, Chudy I Nduaka, Nervin Lawendy, Gary Chan, Rajiv Mundayat, Gary S Friedman, Leonardo Salese ... Show more Journal of Crohn's and Colitis, Volume 15, Issue 6, June 2021,…
05/07/21

Outcome of Ulcerative Colitis 20 Years after Diagnosis in a Prospective Population-based Inception Cohort from South-Eastern Norway, the IBSEN Study

Iril Lovise Monstad, Inger Camilla Solberg, Milada Cvancarova, Oistein Hovde, Magne Henriksen, Gert Huppertz-Hauss, Eva Gunther, Bjørn Allan Moum, Njaal Stray, Morten Vatn ... Show more Journal of Crohn's and Colitis, Volume 15, Issue 6, June 2021, Pages 969–979, Abstract…