20/12/21

Efficacy and Safety of Tofacitinib Re-treatment for Ulcerative Colitis After Treatment Interruption: Results from the OCTAVE Clinical Trials

Julian Panés, Séverine Vermeire, Marla C Dubinsky, Edward V Loftus, Jr, Nervin Lawendy, Wenjin Wang, Leonardo Salese, Chinyu Su, Irene Modesto, Xiang Guo Journal of Crohn's and Colitis, Volume 15, Issue 11, November 2021, Pages 1852–1863 Background and Aims Tofacitinib…
20/12/21

Regular Use of Proton Pump Inhibitor and the Risk of Inflammatory Bowel Disease: Pooled Analysis of 3 Prospective Cohorts

Bin Xia, Man Yang, Long H. Nguyen, Qiangsheng He, Jie Zhen, Yuanyuan Yu, Mengyang Di, Xiwen Qin, Kuiqing Lu, Zi Chong Kuo, Yulong He, Changhua Zhang, Wenbo Meng, Jinqiu Yuan Gastroenterology 2021 Dec;161(6): 1842-1852.e10 Background & Aims Proton pump inhibitors …
20/12/21

The influence of proton pump inhibitor therapy on the outcome of infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies

Thomas X Lu, Matthew Dapas , Erika Lin, Trevor Peters Gut 2021 Nov;70(11):2076-2084. Abstract Objective In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton…
20/12/21

Anti-SARS-CoV-2 Vaccination and Antibody Response in Patients With Inflammatory Bowel Disease on Immune-modifying Therapy: Prospective Single-Tertiary Study

Karin Cerna, MD, Dana Duricova, MD, PhD, Martin Lukas, MD, Nadezda Machkova, MD, Veronika Hruba, MD, Katarina Mitrova, MD, Kristyna Kubickova, MD, Marta Kostrejova, MD, PhD, Vladimir Teplan, MD, PhD, Martin Vasatko, MD ... Show moreInflammatory Bowel Diseases, izab301, https://doi.org/10.1093/ibd/izab301…
12/11/21

BNT162b2 Messenger RNA COVID-19 Vaccine Effectiveness in Patients With Inflammatory Bowel Disease: Preliminary Real-World Data During Mass Vaccination Campaign

Amir Ben-Tov, Tamar Banon, Gabriel Chodick, Revital Kariv, Amit Assa, Sivan Gazit, Collaborators of the Maccabi Institute for Research & Innovation COVID-19 Task Force A 2-dose regimen of the BNT162b2 messenger (m)RNA COVID-19 vaccine (Pfizer-BioNTech; Pfizer, New York, NY) has…
12/11/21

ECCO Topical Review: Refractory Inflammatory Bowel Disease

Tim Raine, Bram Verstockt, Uri Kopylov, Konstantinos Karmiris, Rimma Goldberg, Raja Atreya, Johan Burisch, John Burke, Pierre Ellul, Charlotte Hedin, Stefan D Holubar, Konstantinos Katsanos, Triana Lobaton, Carsten Schmidt, Garret Cullen Abstract Inflammatory bowel disease is a chronic disease with…
12/11/21

Loss of response to anti-TNFa agents depends on treatment duration in patients with inflammatory bowel disease

Summary Background: Inflammatory bowel disease (IBD) is often managed with anti-tumour necrosis factor-therapy (anti--TNFa), but treatment efficacy is compromised by high annual rates of loss of response (13%-21% per patient-year). Aims: To assess whether the incidence of loss of response…
12/11/21

Occurrence of Colorectal Cancer and the Influence of Medical Treatment in Patients With Inflammatory Bowel Disease: A Danish Nationwide Cohort Study, 1997 to 2015

Petra Weimers, MD, Dorit Vedel Ankersen, MSc, Ellen Christine Leth Løkkegaard, PhD, Johan Burisch, PhD, Pia Munkholm, PhDInflammatory Bowel Diseases, Volume 27, Issue 11, November 2021, Pages 1795–1803, Background: The risk of colorectal cancer (CRC) for patients with inflammatory bowel…
12/11/21

The Risk of Later Diagnosis of Inflammatory Bowel Disease in Patients With Dermatological Disorders Associated With Inflammatory Bowel Disease

Dominic King, MBChB, Joht Singh Chandan, PhD, Tom Thomas, MBBD, Krishnarajah Nirantharakumar, MD, Raoul C Reulen, PhD, Nicola J Adderley, PhD, Nigel Trudgill, MDInflammatory Bowel Diseases, Volume 27, Issue 11, November 2021, Pages 1731–1739 Background: Dermatological conditions such as erythema…
10/09/21

Risk of Venous Thromboembolism Among Inflammatory Bowel Disease Patients Who Contract SARS-CoV-2

Nadim Mahmud, MD1,2; Alexandra Weiss, MD2; Chinmay Trivedi, MBBS1; Yu-Xiao Yang, MD1,3; James Lewis, MD2; Nabeel Khan, MD1,2Gastroenterology 2021 Jun 15;S0016-5085(21)03123-1. Introduction : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic affecting over 166 million people…
10/09/21

Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection

JR Allegretti, CR Kelly , A Grinspan, BH Mullish, J Hurtado, M Carrellas, J Marcus, JR Marchesi , JAK McDonald , Y Gerardin, M Silverstein, A Pechlivanis , GF Barker, JM Blanco, JL Alexander, KI Gallagher, W Pettee, E Phelps, …
10/09/21

Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease:long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

Evangelos Stournaras, Wendi Qian , Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators; Tim Raine, Miles Parkes.Gut 2021 Apr;70(4):677-686 Abstract Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base…